MersV1, Main, Exploration, bibRecord, 003216

Genomic occurrence of microsatellites containing integral and non-integral repeat numbers.

Identifieur interne : 003216 ( Main/Exploration ); précédent : 003215; suivant : 003217

Genomic occurrence of microsatellites containing integral and non-integral repeat numbers.

Auteurs : Iva Hrabcová [République tchèque] ; Jaroslav Kypr

Source :

Biochemical and biophysical research communications [ 0006-291X ] ; 2003.

RBID : pubmed:12559947

Descripteurs français

KwdFr :
- Analyse de séquence d'ADN, Animaux, Bases de données d'acides nucléiques, Conformation d'acide nucléique, Génome, Humains, Levures (génétique), Répétitions microsatellites, Souris, Séquence nucléotidique.
MESH :
- génétique : Levures.
- Analyse de séquence d'ADN, Animaux, Bases de données d'acides nucléiques, Conformation d'acide nucléique, Génome, Humains, Répétitions microsatellites, Souris, Séquence nucléotidique.

English descriptors

KwdEn :
- Animals, Base Sequence, Databases, Nucleic Acid, Genome, Humans, Mice, Microsatellite Repeats, Nucleic Acid Conformation, Sequence Analysis, DNA, Yeasts (genetics).
MESH :
- genetics : Yeasts.
- Animals, Base Sequence, Databases, Nucleic Acid, Genome, Humans, Mice, Microsatellite Repeats, Nucleic Acid Conformation, Sequence Analysis, DNA.

Abstract

We calculated occurrences of all dinucleotide and trinucleotide microsatellites in the human, mouse, and yeast genomes. The microsatellites were considered separately not only according to the repeated dinucleotide or trinucleotide and the microsatellite length but also according to the starting/terminal nucleotide. The analysis showed that dramatically non-equal amounts occurred in the human genome of microsatellites that differed only by the terminal nucleotides. For example, the 23-mer (TTG)(7)TT occurs 635 times in the human genome whereas (GTT)(7)GT is present only three times in the human genome though the two 23-mers share a 22 nucleotide sequence. The dramatically non-equal occurrences of microsatellites differing only by the terminal nucleotides are observed for most dinucleotide and trinucleotide microsatellites and in all analyzed genomes. We suppose that the strikingly non-equal genomic occurrences of these closely related microsatellites originate from conformational properties of DNA.

DOI: 10.1016/s0006-291x(02)02940-6
PubMed: 12559947

Affiliations:

République tchèque

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<term>Base Sequence</term>
<term>Databases, Nucleic Acid</term>
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<term>Humans</term>
<term>Mice</term>
<term>Microsatellite Repeats</term>
<term>Nucleic Acid Conformation</term>
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<term>Conformation d'acide nucléique</term>
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<front><div type="abstract" xml:lang="en">We calculated occurrences of all dinucleotide and trinucleotide microsatellites in the human, mouse, and yeast genomes. The microsatellites were considered separately not only according to the repeated dinucleotide or trinucleotide and the microsatellite length but also according to the starting/terminal nucleotide. The analysis showed that dramatically non-equal amounts occurred in the human genome of microsatellites that differed only by the terminal nucleotides. For example, the 23-mer (TTG)(7)TT occurs 635 times in the human genome whereas (GTT)(7)GT is present only three times in the human genome though the two 23-mers share a 22 nucleotide sequence. The dramatically non-equal occurrences of microsatellites differing only by the terminal nucleotides are observed for most dinucleotide and trinucleotide microsatellites and in all analyzed genomes. We suppose that the strikingly non-equal genomic occurrences of these closely related microsatellites originate from conformational properties of DNA.</div>
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Serveur d'exploration MERS

Genomic occurrence of microsatellites containing integral and non-integral repeat numbers.

Genomic occurrence of microsatellites containing integral and non-integral repeat numbers.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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